Pair Name	Gamma-Tocotrienol, Capecitabine
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Gene Regulation	Down-regulation	Expression	BIRC2	hsa329
	Down-regulation	Expression	BIRC3	hsa330
	Down-regulation	Expression	BIRC5	hsa332
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CXCR4	hsa7852
	Down-regulation	Expression	ICAM1	hsa3383
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	MYC	hsa4609
	Down-regulation	Expression	NFKB1	hsa4790
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
In Vivo Model	Luciferase-transfected HCT 116 cells (2×10⁶) in PBS (50 μl) were injected subcutaneously into the leg of each mouse with a 27-gauge needle.
Result	Our findings suggest that γ-T3 inhibited the growth of human CRC and sensitised CRC to capecitabine by regulating proteins linked to tumourigenesis.

Pair Name	Gamma-Tocotrienol, Capecitabine
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Inhibition-->Angiogenesis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	BIRC5	hsa332
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	COX2	hsa4513
	Down-regulation	Expression	CXCR4	hsa7852
	Down-regulation	Expression	ICAM1	hsa3383
	Down-regulation	Expression	MMP9	hsa4318
	Up-regulation	Expression	PARP1	hsa142
	Down-regulation	Expression	RELA	hsa5970
	Down-regulation	Expression	VEGFA	hsa7422
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	SNU-5	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0078
	SNU-16	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0076
	MKN45	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0434
Result	Our results show that γ-tocotrienol can potentiate the effects of capecitabine through suppression of NF-κB-regulated markers of proliferation, invasion, angiogenesis, and metastasis.